Carisoprodol vs Cyclobenzaprine: Which Works Better for Muscle Spasms? (2025)
Carisoprodol (Soma)
Best for: Short-term acute pain (7-10 days max)
Pros:
- Faster onset (30 minutes)
- More sedating (helps with pain-related insomnia)
Cons:
- High abuse potential (Schedule IV controlled substance)
- Not suitable for chronic use
Cyclobenzaprine (Flexeril)
Best for: 2-3 week muscle spasm treatment
Pros:
- Lower risk of dependence
- Better long-term safety profile
Cons:
- Longer half-life (may cause next-day drowsiness)
- Less effective for severe acute pain
“In my practice, I reserve carisoprodol for post-surgical cases where rapid relief is critical, while cyclobenzaprine is my first choice for typical back spasms.” — Dr. Susan Miller, PharmD
Clinical Decision Factors
| Consideration | Carisoprodol | Cyclobenzaprine |
|---|---|---|
| Drug Interactions | High (CYP2C19 inhibitor) | Moderate (avoid with MAOIs) |
| Elderly Patients | Not recommended | Use lower 5mg dose |